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“The HUREL® co-culture can be applied to accurately estimate intrinsic clearance of slowly metabolized drugs and is now utilized as a standard method for in vivo clearance predictions of such compounds in-house.”

–  AstraZeneca, Molecular Pharmaceutics

“In our studies evaluating four low-turnover drugs, the HUREL® co-culture model generated a more robust metabolite profile over seven days than was observed following incubation using hepatocyte suspension.”

–   Q2 Solutions, Drug Metabolism & Disposition


Clarinex®: The Hunt for the Unproducible Metabolite

Interspecies Comparison of DMPK Endpoints


Improved Prediction of Hepatotoxicity (or DILI) Using HUREL® Hepatic Co-cultures

HUREL® Microliver Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds