Long-enduring primary hepatocyte-based co-cultures improve prediction of hepatotoxicity.
Novik E, Dwyer J, Morelli J, Parekh A, Cho C, Pludwinski E, Shrirao A, Freedman R, MacDonald J and Jayyosi Z. Toxicology and Applied Pharmacology, 336 (2017) 20-30 (view paper/download)
Determination of human hepatocyte intrinsic clearance for slowly metabolized compounds: comparison of a primary hepatocyte/stromal cell co-culture with plated primary hepatocytes and HepaRG.
Bonn B, Svanberg P, Janefeldt A, Hultman I, and Grime K. Drug Metab Dispos. 44:527–533, April 2016. (view paper/download)
Use of HUREL™ human co-culture system for prediction of intrinsic clearance and metabolite formation for slowly metabolized compounds.
Hultman I, Vedin C, Abrahamsson A, Winiwarter S and Darnell M. Molecular Pharmaceutics 2016, 13, 2796−2807. (view paper/download)
Troglitazone metabolism and the impact of its metabolites on taurocholic acid transport in the HURELflux™ primary human hepatic co-culture system.
Plise E, Takahashi R, Chen E, Chang J, Cheong J and Salphati L. Poster presented at: AAPS/ITC Drug Transporter Workshop, April 2016. (view paper/download)
Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans
Atienzar F, Novik E, Gerets H, Parekh A, Delatour C, Cardenas A, MacDonald J, Yarmush M and Dhalluin S. Toxicology and Applied Pharmacology, 175 (2014) 44-61.
“Which models to use in Early Toxicology Assessment to detect Human Hepatotoxic Drugs?”
Atienzar F, slide presentation, ADME and Predictive Toxicology 2013. Barcelona, 11 April 2013. (view paper/download)
Design and Application of Microfluidic Systems for In Vitro Pharmacokinetic Evaluation of Drug Candidates
TMaguire TM, Novik E, Chao P, Barminko J, Nahmias Y, Yarmush ML and Cheng KC. Current Drug Metabolism, 2009, 10. (view paper/download)
A Microfluidic Hepatic Coculture Platform for Cell-based Drug Metabolism Studies
Novik E, Maguire TJ, Chao P, Cheng KC, Yarmush ML. Biochem Pharmacol. 2009 Nov 16. (view paper/download)
Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.
Kidambi S, Yarmush RS, Novik E, Chao P, Yarmush ML, Nahmias Y. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15714-9. (view paper/download)
Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human
P. Chao, T. Maguire, E. Novik, K.-C. Cheng and M.L. Yarmush Biochem Pharmacol. 2009 May 19. (view paper/download)
A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers.
Tatosian DA, Shuler ML Biotechnol Bioeng. 2009 May 1;103(1):187-98. (view paper/download)
Real-time fluorescence detection of multiple microscale cell culture analog devices in situ.
Oh TI, et al. Cytometry A. 2007 Oct;71(10):857-65. (view paper/download)
Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies.
Viravaidya K, et al. Biotechnol Prog. 2004 Mar-Apr;20(2):590-7. (view paper/download)
An In Vivo-Surrogate Assay Platform for Cell-based Studies
Baxter GT, Freedman RM American Biotechnology Laboratory, February, 2004. (view paper/download)
The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors.
Sin A, et al. Biotechnol Prog. 2004 Jan-Feb;20(1):338-45. (view paper/download)
Development of a microscale cell culture analog to probe naphthalene toxicity.
Viravaidya K, et al. Biotechnol Prog. 2004 Jan-Feb;20(1):316-23. (view paper/download).